Sunitinib was given in an intermittent schedule 4/2 (6-week cycle, 4 weeks on treatment, 2 weeks off treatment). The dose was reduced to 37.5 mg per day at the next treatment cycle. The patient developed the same clinical picture after re-initiating treatment. During the 2 weeks off period, a spontaneous regression of the serous detachment occurred again. Even after the reduction of sunitinib to 25 mg per day, the same 'yoyo-effect' was observed.The patient was receiving anti-hypertensive treatment at that time that included a selective beta-blocker (bisoprolol), an angiotensin-converting enzyme inhibitor (ramipril) and an angiotensin II receptor antagonist (candesartan). None of them was discontinued at any time the patient received sunitinib. The patient did not take any corticosteroids. Blood pressure was well controlled (130/80 mm Hg).Blood count, electrolytes, liver, and kidney function parameters were within normal range.The underlying mechanisms of subretinal exudation are thought to include changes of the choroidal vascular permeability and choroidal vascular perfusion. 3,4 Any medication, which can cause such changes, may be liable to induce serous retinal detachments. This is, to the best of our knowledge, the first report of a reversible neurosensory retinal detachment and retinal oedema due to sunitinib. Neovascular age-related macular degeneration and macular oedema due to vascular occlusion are the main indication for treatment with anti-VEGF in ophthalmology. Serous retinal detachment has not been reported as a side effect when using these substances. Moreover, neurosensory retinal detachment can even be treated with anti-VEGF. 5 This might suggest that not the anti-VEGF-receptor effect of sunitinib was responsible for the neurosensory retinal detachment but other properties of its spectrum of action.
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