Introduction: Jaundice comes from the Greek, a clinical condition with skin color and mucosa to become yellowish. The cases number of obstructive jaundice with choledocholithiasis at Hasan Sadikin Hospital Bandung-Indonesia from 2014 to 2016 were 132 cases. On the other hand, honey and vitamin C, which are supplements that are easy to locate in Indonesia, have antioxidant and hepatoprotective abilities to inhibit liver fibrosis and reduce MDA levels effectively, which is one indicator of lipid peroxidation. Therefore, this study tried to compare the role of honey with vitamin C in inhibiting the occurrence of liver fibrosis and lipid peroxidation. Methods: This study was an experimental study with a parallel design that aimed to determine the formation of liver fibrosis and plasma malondialdehyde (MDA) values as an indicator of lipid peroxidation in biliary obstruction conditions given honey and vitamin C (treatment group) and without honey and vitamin C (control group) in Wistar rats. Results: Giving honey 3 mg and vitamin C 225 mg in biliary obstruction for 14 days gave an inhibitory effect on liver fibrosis and lower plasma MDA levels compared to the control group. Also, honey had an inhibitory effect on fibrosis and lower plasma MDA levels compared to vitamin C. Conclusions: Oral administration of 3 mg honey in biliary obstruction of Wistar rats had better results than 225 mg of vitamin C in inhibiting liver fibrosis and lipid peroxidation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.