Cotinus coggygria Scop. is a medicinal plant which contains a variety of precious phytochemical compounds applicable in traditional medicine. The aim of this study is to investigate the cytotoxic effect of Cotinus coggygria Extract on Hep3B cancer cells. The cytotoxic effect was measured by MTT assay. Based on IC 50 values, the C.coggygria leaf extract showed cytotoxic effect on Hep3B cancer cells, which was found better at 24h (IC 50 = 3.642) then at 48h (IC 50 = 3.956). Also, the dose of C. coggygria extract showed negative correlation (p<0.05) with cell viability of 24h and 48h and positive correlation (p<0.05) with cytotoxic effect of 24h and 48h.The cytotoxic effects were concentration-time dependent. ccording to our study, C. coggygria extract had protective effect at 24h on AML12 cell line and cytotoxic effect on the Hep3B cancer cell line, where it indicates that it may have an antitumorigenic effect.
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