S Su ur rf fa ac ct ta an nt t p pr ro ot te ei in n--A A l le ev ve el ls s i in nc cr re ea as se e d du ur ri in ng g P Pn ne eu um mo oc cy ys st ti is s c ca ar ri in ni ii i p pn ne eu um mo on ni ia a i in n t th he e r ra at t There was a severalfold increase in SP-A protein and mRNA levels in uninfected glucocorticoid-treated rats. However, contrary to what has been reported with the surfactant-associated lipids, SP-A mRNA and protein levels in P. carinii-infected animals were significantly higher than those found in the uninfected, immunosuppressed animals.Our results demonstrate that SP-A increases, probably as a result of elevated mRNA levels, in immunosuppressed rats with P. carinii infection and are consistent with our findings in HIV-positive patients with P. carinii pneumonia.
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