Aims: The present study investigated the potential nephroprotective activity of aqueous and hydroethanolic extracts of Trema guineensis leaves (Ulmaceae) and determined the most active extract in rat.

The present study investigated the preventive effect of Trema guineensis on serum concentrations of vitamins A, D and E during hepatotoxicity in rat. The leaves of Trema guineensis collected from Abobo in the district of Abidjan were used for the preparation of the aqueous extract by decoction and ethanolic extract by maceration. Then, healthy adult Wistar albino rats were used for the experimentation. The animals were pretreated with the extracts at the doses of 100 and 200 mg/kg of body weight by oral route one hour before CCl4 intraperitoneal injection for seven days. The administration of CCl4 resulted in a significant decrease of vitamins A, D and E rates in the serum while the pretreatment by the extracts increased the concentrations of these vitamins. The extracts of Trema guineensis would prevent vitamins A, D and E deficiency in serum due to hepatic injury.

This study was undertaken to determine vitamins A, D and E composition of aqueous and ethanolic extracts of Trema guineensis and effect of supplementation of these extracts on serum concentrations of these vitamins. Aqueous and ethanolic extracts of Trema guineensis were obtained by decoction and maceration of leaves powder, respectively. Then, they were administered to animals at doses of 100 and 200 mg/kg body weight against a control group treated with distilled water for two weeks. Composition of vitamins in extracts and serum concentrations of vitamins A, D and E were performed by HPLC. Results showed that Trema guineensis extracts contained high concentrations of vitamins A, D and E. Thus, vitamins A and D serum concentrations were weakly influenced while that of vitamin E increased strongly during administration of Trema guineensis extracts. This study therefore showed that extracts of Trema guineensis had vitamins A, D and E and a beneficial effect on serum concentrations of these vitamins.

Aims: Gentamicin, a widely used aminoglycoside antibiotic, is recognized as possessing significant nephrotoxic potential in human beings. The aim of this study was to determine the protective effect of aqueous and hydroethanolic extracts of Crinum scillifolium on gentamicin induced nephrotoxicity using biochemical approaches and determined the most active extract in rat. Study Design: The leaves of Crinum scillifolium were collected in the district of Me (Côte d’Ivoire). The plant was identified and authenticated by the Department of Botany, Felix Houphouet Boigny University of Abidjan (Côte d’Ivoire). Place and Duration of Study: Analysis of the plant samples was done in pharmacodynamics Biochemistry Laboratory, Felix Houphouet Boigny University and the Laboratory of Organic Chemistry and Natural Substances, Felix Houphouet Boigny University between July and August 2018. Methodology: The extractions were execcuted by macerating 100 g of plant dry powder in 1 liter of distilled water (aqueous extraction) or in 2 liters of water / ethanol mixture (30/70 V / (ethanol extraction). The animals were divided according to weight in seven groups each of six rats. The nephroprotective effects were estimated by comparing the effects of the extracts (100 and 200 mg / kg) to that of vitamin E (250 mg / kg) against gentamicin-induced renal failure by (80 mg / kg). Gentamicin is administered to the animals one hour after treatment with the extracts for seven days. Results: The administration of gentamicin through intraperitoneal route to rats for seven days, resulted in an increase in urea and creatinine concentrations as well as decrease of total protein concentration in the serum. The level of total protein and albumin increased in urine after administration of gentamicin. The treatment of animals suffering from nephrotoxicity with Hydroethanolic and aqueous extracts of Crinum scillifolium would have significantly reduced (P < 0.001 and P < 0.01) biochemical parameters considered as markers of nephrotoxicity. Conclusion: This study proved that the aqueous extract of Crinum scillifolium possesses a nephroprotective activity against gentamicin-induced kidney failure in rats. So aqueous extract can be useful for preventives applications.

This study was conducted to evaluate Trema guineensis leaves efficacy in preventing CCl

No abstract

No abstract

Widely used in Ivory Coast and sub-Saharan Africa in traditional medicine as anti-inflammatory, antioxidant, laxative and purgative, Erythrococca anomala (Euphorbiaceae), is an annual plant. In this work, the aim was to evaluate the Hepatoprotective activity of the aqueous and hydroethanolic extracts of the leaves. Carbon Tetrachloride (CCl 4 ) was used to induce hepatotoxicity in rats. This hepatotoxic effect causes a significant increase in the levels of liver enzymes and serum proteins. Hepatoprotective activity was assessed by assaying liver enzymes such as serum transaminases (alanine aminotransferase and aspartate aminotransferase) and proteins by spectrophotometric and electrophoretic techniques. When administered orally as a preventive and curative dose of 100 and 200 mg / kg body weight, the extracts significantly reduce significantly as silymarin, the reference hepatoprotective substance at 100 mg / kg bw, hepatotoxicity induced by Carbon tetrachloride (CCL 4 ) at a dose of 5 mg / kg bw after a significant reduction in liver enzyme levels, globulins and a significant increase in albumin. The possible mechanism of this hepatoprotective activity of the extracts may be due to the action of the antioxidants such as the flavonoids, the phenols present in the extracts.