Baron F, Storb R. Allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning as treatment for hemato-logic malignancies and inherited blood disorders.
appear in the yolk sac and the fetal liver without affecting differentiation. 4 However, additional genetic aberrations are needed to induce leukemia, as individuals with a germline splicing mutation of GATA1 only show a macrocytic anemia and neutropenia, but no leukemia. 3 Therefore, it needs to be tested whether JAK3 mutations can induce a leukemic phenotype in cooperation with GATA1s in a mouse model. As others and we could only verify these mutations in a small subgroup of ML-DS patients, we propose that other, yet unknown, cooperating factors on the background of trisomy 21 are required for oncogenesis. Further research needs to be carried out to identify these factors.
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