Osteoarthritis is a degenerative disorder.It is more commonly affecting women and the severity of the disease depends on the age. It mostly affects the cervical ,lumbosacral and knee joints.Osteoarthritis of knee joint seen in elderly people leads to impaired mobility.Life stylemodifications,exercise and analgesics can be tried for management of the disease before going to permanentcure by joint replacement surgery which is cost effective.Analgesics like diclofenac,lornaxicum are used in the reduction of inflammatory responces in joints.It was showed that lornaxicum is more beneficial and safest drug than diclofenacwhich may cause cardiovascular problem in chronic usage. The present study was conducted to compare theefficacy and safety of lornaxicam and diclofenac in newly diagnosed patients of osteoarthritis.
The total 50 patients aged 35-70, were enrolled into the study group and 50 age, sex matched healthy individuals were enrolled as control group and they were analysed for the lipid profiles. The study group was randomly allocated into 2 groups as group A (n=25) and group B (n=25). GroupA received the drug Rosuvastatin 10mg and the groupB received the drug Atorvastatin 10mg. The patients were followed for 12 weeks.. There were no drop outs in both the study groups in the present study. Comparison was made regarding the reduction in the LDL-C, Total cholesterol, VLDL-C and Triglycerides, and improvement of of HDL-C,and side effects. Statistical analysis was done using the paired student 't' test for comparing the lipid profiles of the two groups before and after treatment. The results of the study showed that Rosuvastatin is better than Atorvastatin to treat dyslipidemias in terms of efficacy in lowering the lipid profiles and more safer for side effects.
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