Illumination by acetylene: Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring (S,E)-icos-4-en-1-yn-3-ol allowed the discovery of a series of 3R-like 1,4-di-unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.

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The inside cover picture shows how a chemistry driven study inspired by marine acetylenic lipids isolated from the sponge Cribrochalina vasculum led to the identification of chiral alkynylcarbinol pharmacophores for potent cytotoxicity against HCT116 colon cancer cells. Chirality has a pronounced effect on activity, with the non‐natural (R)‐like configuration giving more cytotoxic derivatives. For more details, see the Communication by Remi Chauvin, Yves Génisson et al. on