The mean average difference previously recorded between blacks and whites on intelligence may be an artifact based upon the differences in education and socioeconomic position of blacks and whites in this country. Previous studies in this area, with a few exceptions, have been comparing
lower class blacks with second-third through tenth generation middle class whites. Only recently in this country has a true black middle class emerged that has had access to both education and income. Even though black income nationally is still only 61% of white income, the black middle
class income has approached 75% of white income. This increase in disposable income is being invested in youth development. Second generation black youth of middle class status will show many attributes of the American achievement syndrome. The black youth in this study exceeded the
white sample mean on the Stanford-Binet and the WISCR. The black mean was 128.63 with a standard deviation of 14.44, while the white mean was 115.75 with a standard deviation of 13.37. The difference was significant at the 0.001 level.
Immune thrombocytopenia is frequently encountered in medical practice and is generally accepted as being caused by an IgG antibody. The capability of detecting platelet-bound IgG as a diagnostic and therapeutic modality is critical for appropriate care and management of patients with idiopathic thrombocytopenic purpura (ITP), as well as other immune thrombocytopenias. We have modified our previous assay (Br J Haematol 37:265, 1977) by employing protein A and PAP as a labeled antibody. Surface bound platelet IgG was quantitated by phase contrast microscopy after incubation with PAP, graded per 100 platelets and expressed as a reactive index (RI). Controls (n=13) had RIs ranging from 0.49 to 0.72 (mean 0.63 +/- 0.02 SE). The nonimmune thrombocytopenic group (n=7) had an RI ranging from 0.58 to 0.72 (mean 0.64 +/- 0.01 SE). In contrast, the immune thrombocytopenic group (n=28) had RIs ranging from 1.04 to 1.75 (mean 1.43 +/- ;0.03 SE). Platelet-associated IgG was evaluated further by absorbing representative sera samples from each group against washed granulocytes, red cells and platelets. Only when sera from the immune thrombocytopenic group were absorbed against platelets did the reactive indices of pre- and postabsorption samples change significantly. These findings suggest that our assay is clinically applicable in detecting platelet-associated IgG in immune thrombocytopenia and has the advantage of being rapid, reproducible and easy to perform in a clinical laboratory.
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