The functions of the D1- and D2-dopamine receptors in the basal ganglia have remained somewhat enigmatic, with a number of competing theories relating to the interactions of the 'direct' and 'indirect pathways'. Computational models have been good at simulating properties of the system, but are typically divorced from the underlying neural architecture. In this article we propose a new model which re-addresses response selection at the level of the basal ganglia. At the core of this response selection system the D1 DA receptor-expressing striatal pathways 'prepare' the set of possible appropriate responses. The D2DR-expressing striatal pathways then shape and 'select' from this initial response set framework. This article is part of a Special Issue entitled: Ventral Tegmentum & Dopamine.
The sexological research questionnaire, which became a central research tool in twentieth-century sexology, has a methodological-developmental history stretching back into mid-nineteenth century Germany. It was the product of a prolonged, disruptive encounter between sexual scientists constructing sexual case studies along with newly assertive homosexual men supplying self-penned sexual autobiographies. Homosexual autobiographies were intensely interesting to these men of science but lacked the brevity, structure, and discipline of a formal clinical case study. In the closing decades of the century, efforts to harness and regularize this self-penned material resulted in a series of methodological adaptations. By the turn of the century this process had resulted in the first use of a formal sexual research questionnaire.
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