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T W O FIGCRESReptiles have been utilized a s experimental animals for research in problems of reproduction and endocrinology mucli less than have fish, amphibians, birds, and mammals. C. R. Moore's statement in the first edition of Sex and Interma1 Secretions ('32) that "we know less perhaps about the physi-

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2 -Ethyl-5-methylbenzimidazole was found to be considerably more inhibitory than 2,5-dimethylbenzimidazole, or benzimidazole, for the synthesis of heme by chicken erythrocytes incubated in vitro. This was in the same relative order of inhibitory activities as was noted for multiplication of influenza A or B virus, and is considered to add further support to the concept that the same basic mechanism, possibly involving a fundamental role of nucleic acid in biosynthesis, underlies both processes.

1. Activity of the specific alkaline phosphatase, 5-nucleotidase, is intense in the epithelium and secretion of the rattlesnake venom gland. Non-specific alkaline phosphatase activity is lacking. 2. Thyroid epithelium, the smooth muscle of great vessels, and (inconstantly) smooth muscle of abdominal hollow viscera show greater 5-nucleotidase than nonspecific activity. 3. These findings confirm the specificity of 5-nucleotidase.