Combination therapy has been regarded as a promising strategy for cancer treatment due to the enhanced anticancer efficacy achieved by blocking multiple drug resistance pathways. In this work, a drug carrier based on nanoscale ZIF-90 for the codelivery of two anticancer drugs has been synthesized by covalently attaching doxorubicin (DOX) to the surface of ZIF-90 via Schiff base reaction of amino group in DOX and aldehyde group of imidazole-2-carboxaldehyde (ICA) ligand and encapsulating 5-fluorouracil (5-FU) into the pores of the framework. The results of drug loading measurements show that the loading amount of drugs was estimated as high as 36.35 and 11-13.5 wt % for 5-FU and DOX, respectively. Moreover, we demonstrated that the carrier had the potential of cancer-targeted delivery of drugs for the collapse of framework under the pH environment around cancer cells and subsequently releasing drugs. Drug release at pH 5.5, imitating the environment of tumor, can reach over 95%, and the release time is less 16 h, meaning a more effective and faster release of drugs around tumoral cells than that in a normal environment. This is the first report for cancer-targeted codelivery of two different chemical drugs based on nanoscale metal-organic frameworks (NMOFs).
Carbon nanodots (CDs)
have attracted enormous attention in the
photocatalytic area for their high light-harvesting and outstanding
electron transfer abilities. In this work, NH2–UiO-66
was first composited with g-C3N4 to construct
an NH2–UiO-66/g-C3N4 heterojunction.
Then, CDs were incorporated into the pores of NH2–UiO-66
by the pore space of the framework serving as confined nanoreactors
to construct a CD@NH2–UiO-66/g-C3N4 ternary composite. The ultrasmall CDs transformed from incapsulated
glucose in the pores of NH2–UiO-66 were uniformally
distributed in MOFs and extensively improve the photocatalytic hydrogen
evolution activity of the composite under visible-light irradiation.
The optimum photocatalytic H2 evolution rate of the CD@NH2–UiO-66/g-C3N4 composite with
a CD content of 2.77 wt % is 2.930 mmol·h–1·g–1 under visible-light irradiation, which
is 32.4, 38.6, and 17.5 times as high as that of bulk g-C3N4, NH2–UiO-66, and NH2–UiO-66/g-C3N4, respectively. The remarkable enhancement of
the photocatalytic activity should be that CDs as cocatalysts effectively
increase the transport properties of electrons and efficient charge
separation. Moreover, CD@NH–UiO-66/g-C3N4 nanocomposites showed excellent stability during the photocatalytic
process as determined by XRD and TEM analyses for the sample after
reaction. The results of the mechanism investigation reveal that CDs
in the ternary composite serve as electron transfer mediation to facilitate
charge separation, enhancing light absorption and extending the lifetime
of photoinduced carriers. The present work shows that encapsulating
CDs into the pores of MOFs is an efficient strategy to improve the
activity of an MOF-based photocatalyst.
Tea waste could be used as an effective and economic substrate for oyster mushroom cultivation. This study also provided a useful way of dealing with massive amounts of tea waste.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.