disrupted cytoskeleton, absence of normal intracellular ion concentrations, and different membrane tension compared with the whole cell.In short, there is no single ideal in vitro system for replacing the human neuromuscular junction. However, we believe that by using comparative in vitro pharmacology one can qualitatively describe clinically relevant pharmacological interactions on the cellular level. This is possible without resolving the exact distribution between multiple desensitized states.
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