The validity of a developmentally based life-stress model of depression was evaluated in 88 clinic-referred youngsters. The model focused on (a) the role of child–environment transactions, (b) the specificity of stress–psychopathology relations, and (c) the consideration of both episodic and chronic stress. Semistructured diagnostic and life-stress interviews were administered to youngsters and their parents. As predicted, in the total sample child depression was associated with interpersonal episodic and chronic stress, whereas externalizing disorder was associated with noninterpersonal episodic and chronic stress. However, the pattern of results differed somewhat in boys and girls. Youngsters with comorbid depression and externalizing disorder tended to experience the highest stress levels. Support was obtained for a stress-generation model of depression, wherein children precipitate stressful events and circumstances. In fact, stress that was in part dependent on children's contribution distinguished best among diagnostic groups, whereas independent stress had little discriminative power. Results suggest that life-stress research may benefit from the application of transactional models of developmental psychopathology, which consider how children participate in the construction of stressful environments.

Because of both methodological and theoretical limitations, previous studies of offspring of parents with affective disorders have rarely tested psychosocial models of depressive vulnerability. The current research is part of a longitudinal investigation of psychosocial risk for disorder in 8-to 16-yearold children of unipolar, bipolar, medically ill, and normal mothers. High rates of psychopathology, including depression, were found in children in the high-risk groups. The current study evaluated the separate contributions of maternal depressive history, current self-reported depressive symptoms (Beck Depression Inventory scores), and chronic strains to observe relations between these ordinarily confounded variables and children's psychiatric diagnoses and current functioning. Hierarchical regression analyses indicated that chronic strain added significantly to the prediction of several outcomes and that current depressive symptoms were more predictive of children's scores than was maternal history of affective disorder. Both chronic strains and current Beck Depression Inventory scores are viewed as concomitants of affective disorder but are not specific to it. Therefore studies of the risk to children conferred by parental disorder cannot assume that diagnostic status as such is a single risk factor and must attend to the effects of ongoing stressors and nonspecific symptoms.One path in the search for origins of and preventive interventions for depression leads to the study of vulnerabilities that children at high risk acquire during childhood. Although evidence is mounting that children of parents with affective disorders are at risk for increased psychopathology, especially depression (e.g., reviews by Beardslee, Bemporad, Keller, & Klerman, 1983;Morrison, 1983;Orvaschel, Weissman, & Kidd, 1980), the magnitude and mechanisms of such risk remain unclear. In particular, few studies of the associations between parental diagnostic status and child outcome have examined two variables that may be associated with parental diagnosis but may also exist independent of parental psychiatric status: ongoing family stress and parental depressive symptoms. Although these variables overlap with parental psychiatric conditions, they may contribute separately or differentially to children's outcomes.Family stresses, including chronic strains, negative life This research was funded in part by a Veterans Administration research grant to

The effects of depression and Axis I comorbidity on subsequent self-generated life stress were examined in a longitudinal sample of 134 late adolescent women. The results indicated that specific forms of psychopathology constitute a risk factor for future self-generated episodic stress, even when controlling for prior chronic stress. Comorbid depression had a particularly salient effect in the prediction of stress related to interpersonal conflicts. The effects of family psychopathology and sociotropy were mediated through participant psychiatric status, whereas autonomy made an independent contribution to the prediction of episodic stress. These results support C. Hammen's (1991b) stress generation model in a community sample, demonstrating how individuals with depression play a role in the creation of stress, and also refine prior work by showing that only the comorbid form of depression is associated with subsequent conflict-related stress.

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The authors examined C. Hammen's (1991) model of stress generation in depression and the role of interpersonal problem-solving strategies (IPS) in the stress generation process in a longitudinal sample of 140 young women who entered the study at ages 17-18. Structural equation modeling was used to test a model in which IPS and subsequent interpersonal stress mediated the relationship between initial and later depressive symptoms. Results supported the main prediction of the stress generation model: Interpersonal stress mediated the relationship between initial and later depressive symptoms. In addition, IPS predicted interpersonal stress. However, no association was found between depressive symptoms and IPS. An alternative model in which IPS moderated the relationship between stress and depressive symptoms was tested; it was not supported.