The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.
Context. Underweight, overweight and obesity are important global public health issues and risk factors for adverse perinatal outcomes. Objective. To assess the distribution of the body mass index (BMI) in the Romanian obstetric population in the first trimester of pregnancy and its correlation with pregnancy outcomes. We also report the distribution of blood pressure (BP) parameters and their correlation with BMI. Design. This retrospective study includes 9,064 women attending routine first trimester visit and ultrasound scan at 12.8(±0.6) gestational weeks. Characteristics, parity, method of conception, blood pressure (from 3,650 women), maternal weight and height, BMI and foetal ultrasound were recorded. Pregnancy outcomes were available for 1,607 deliveries. The Pearson correlation coefficient was assessed for each BMI group vs. blood pressure parameters, gestational age and birth weight. ANOVA analysis and post hoc tests were used to determine group differences. Linear regression was applied to estimate the contribution of BMI and gestational age to birth weight variance. Results. In our population, 66.37% pregnant women had a normal BMI, 19.29% were overweight, and 7.56% were obese. There was a weak-to-medium positive correlation between BMI and blood pressure parameters, for all weight categories. The correlation between maternal BMI and birth weight was positive for normal and overweight. Conclusions. Our findings highlight the need for more effective health strategies targeting reduction of weight-related problems in women of childbearing age.
and thrombosis due to blood-material contact. Specifically the ATH was attached to the PDMS using dopamine as a 'bio-glue'. Materials and methods PDMS discs were incubated in a solution of dopamine hydrochloride and then in ATH solution. A separate set of PDMS discs were justed incubated in ATH. Uptake of ATH and adsorption of antithrombin (AT) from plasma (a measure of anticoagulant activity) to the various surfaces was measured using 125 I-labelled ATH and AT. Stability of ATH on surfaces was evaluated by measuring residual radioactivity after incubation in blood. Results ATH uptake on PDMS was higher with dopamine as glue (Fig. 1),~74% of the original ATH was lost from PDMS +ATH after 3 h in blood, whereas only~30% was lost from PDMS+DOP+ATH.The ATH surface with dopamine is adhesive, thus showed higher AT adsorption (42.3 ng/cm 2 ) compared to PDMS (6.3 ng/ cm 2 ), and therefore should have higher anticoagulant activity. Conclusions An antithrombin-heparin complex (ATH) was attached to PDMS using dopamine as a bio-glue. The use of dopamine gave surfaces with higher concentration and greater stability of ATH. The bound ATH showed potential for anticoagulant activity through extensive adsorption of antithrombin from plasma. Background and aim Current guidelines recommend selfinflating bags (SIB), flow-inflating bags and T-piece resuscitators for manual ventilation of neonates. They further recommend the use of PEEP. Using a SIB, PEEP can be provided by attaching a PEEP valve to the device. These valves are mostly reusable items. However, several studies could show that multi-use PEEP valves could only deliver insufficient levels of PEEPand that their reliability was further decreased by repeated sterilisation cycles. PO-0760 RELIABILITY OF SINGLE-USE PEEP VALVES DURING MANUAL VENTILATION OF NEONATESThe aim of our study was to test whether single-use PEEP valves reliably delivered the set PEEP. Results The valves delivered a mean (SD) PEEP of 3.5 (1.9) cmH 2 O when set to 5 cmH 2 O and 5.6 (2.9) cmH 2 O when set to 10 cmH 2 O. One valve could not deliver any PEEP, the second valve from the same manufacturer could only deliver 0.0 (0.0) and 1.4 (0.0) cmH 2 O when set to 5 and 10 cmH 2 O, respectively. Conclusion Single-use PEEP valves could be used as an alternative to multi-use items to avoid damage caused by repeated sterilisation procedures. However, they could not reliably deliver the set PEEP. Operators should be aware of the valves' poor reliability and test them before each use. Background Bronchopulmonary dysplasia (BPD) and WilsonMikity syndrom (WMS) are specific respiratory diseases in premature infants, and utilisation of advanced management techniques will increase the prognosis and life expectancy in children with BPD and WMS. Aim To assess clinical features and impact of BPD and WMS on the appearance of chronic pulmonary diseases in premature children. Methods The study pressents the results of a clinical and evolutive analysis of 10 children with BPD and 4 with WMS that were born premature with a b...
Neonatal hemorrhagic syndrome, which affects several principal organs during the early neonatal period, denotes a deficiency of vitamin K and coagulation factors. This article presents the case of a patient who gave birth at term, had congenital heart disease and required several prior surgical interventions including corrected transposition of the great vessels via ventricular septal defect (VSD) repair, atrial septal defect (in childhood) and tricuspid valve replacement (6 years ago), mitral regurgitation (MR), grade I pulmonary regurgitation (PR), grade II mitral and tricuspid valve regurgitation, and grade II heart failure based on the New York Health Association (NYHA) classification. Throughout the pregnancy, the patient received large doses of anticoagulant, specifically acenocumarolum, until the moment she gave birth. The vaginal delivery was spontaneous, contrary to the recommendations given to the pregnant woman in a secondary healthcare institution. At birth, the newborn was in satisfactory condition, with 8/9 on the Apgar score. However, the newborn’s condition worsened over time, suspected of having neonatal hemorrhagic syndrome caused by medications received by the mother. Forty-eight hours after birth, the newborn died. Anticoagulant therapy cannot be regarded as 100 percent risk-free during pregnancy due to the potential for hemodynamic disorders to develop in both the mother and the unborn child. Considering the high incidence of perinatal mortality in such cases (10-30%), it is advised that a multidisciplinary team work together to inform the mother about potential complications, collaboratively determine the length of treatment with vitamin K antagonists (VKAs), develop a plan for monitoring the pregnancy, and determine which institution the mother and newborn would benefit from receiving qualified medical assistance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.