Segregation analysis of the offspring of balanced translocation carriers was performed on 327 pedigrees collated from published sources and personal communications. Correction was made for bias of ascertainment. Translocations studied involved chromosome arms 1p, 4q, 6p, 6q, 7p, 8p, 10p, 10q, 11q, 14q, 16q, and 17p. Findings included similar rates of occurrence of abnormal liveborn offspring in male and female carriers except for a reduction of risk in male carriers of translocations segregating by 3:1 mode; an elevated risk of fetal loss (spontaneous abortions and stillbirths) in female carriers of 6q, 11q, and 16q translocations compared to male carriers of these translocations; a fetal loss rate exceeding general population estimates in female carriers of 6q and 10q translocations and in male carriers of 6p, 8p, 10q, and 14q translocations including a rate of nearly 50% among female 6q translocation carriers; a higher than expected number of balanced carriers among liveborn offspring; and a low risk of abnormal liveborn children among carriers ascertained by means other than through unbalanced probands. We propose that some translocation carriers may be helped by consideration of more specific empiric risk figures than have traditionally been used.
Annual drawdown of crayfish culture ponds to plant forage crops also serves to eradicate most predaceous finfish. Without annual drawdown predaceous fish populations may reach numbers that can significantly reduce the crayfish crop. Frequent drawdown may not be feasible or desirable in some management schemes. Evidence in the literature suggests that differential toxicity of rotenone would allow removal of fish without harming crayfish in the same pond. In the current study, laboratory and in situ acute toxicity bioassays (96 h) were conducted with 5% non‐synergized emulsifiable rotenone to define the maximum non‐lethal concentration (LC100) for white river crayfish Procambarus acutus acutus and the minimum lethal concentration (LC100) for white perch Morone americana. Six concentration levels of rotenone formulation were tested in each of six toxicity trials with crayfish using dechlorinated tap water at 21–25 C. LC0 (compensated for control mortality) was determined to be 3.0 mg/L. Significant crayfish mortality began at 4.0 mg/L. Acute toxicity to white perch was anticipated to be within recommended concentration levels on product label for similar fish, and was corroborated by laboratory bioassay (LC100 of 0.15 mg/L). Both species were then tested together in laboratory aquaria utilizing pond water at room temperature. Concentration levels of 0.05–2.5 mg/L killed all white perch with no crayfish mortality. In the final phase of the study a 1.0 mg/L concentration of rotenone was applied to a pond containing both species held in cages. All white perch were dead within 24 h; no crayfish mortality was observed for the 96‐h duration of the trial. It may therefore be possible to use this rotenone formulation to control white perch and other finfish in active crayfish culture ponds.
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