Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro-holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue.
Erythema ab igne is a condition characterized by skin changes due to chronic
exposure to moderate temperature. We describe a female patient with continuous
use of a laptop computer on exposed legs for 6 months and consequent development
of reticulated hyperpigmentation at the area. Histopathological examination
revealed epidermal atrophy, collagen fragmentation, and vacuolar changes in the
basal layer, among other signs. We consider this case to be a modern cause of
erythema ab igne.
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