AD+CVD is likely to be under-recognised in Asia. Further research is needed to establish the true prevalence of this treatable and potentially preventable disease.

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We present a comparative experimental analysis of the thermal spectroscopic characteristics of a phosphosilicate (P)-based ytterbium-doped fiber (YDF) against an aluminosilicate (Al)-based YDF in the temperature range of 25 to 150ºC. We also characterize the fibers as gain media in a cladding-pumped amplifier configuration. While both fibers exhibit comparable trends in their thermal characteristics, there are noticeable distinctions in the fluorescence lifetime reduction rate and the spectral dependence of the transition cross-sections. The P-and Al-based YDFs present thermal lifetime reduction rates of 0.012%/ºC and 0.026%/ºC, respectively. In particular, in the spectral region at ~940 nm, the absorption cross-section of the P-based YDF undergoes significantly less thermal change compared to that of the Al-YDF. In the cladding-pumped amplifier configuration operating at a total gain of 10 dB, the Al-based YDF generally performs betters than the P-based YDF in the temperature range of 25 to 75ºC. However, it is highlighted that in the high temperature range of over 75ºC, the latter shows a less gain reduction rate than the former, thereby yielding higher relative output power by 3.3% for a 1060-nm signal, for example.

Purpose: To investigate the causes of isolated ocular motor nerve palsy in patients with a history of cancer.Methods: The charts of 30 patients with cancer diagnosed with isolated acquired third, fourth, and sixth cranial nerve palsies from March 2013 to December 2021 were retrospectively reviewed. Sex, age of onset, underlying disease and causes of cranial nerve palsy were analyzed.Results: Sixth cranial nerve palsy (n = 18, 60.0%) was the most common. Brain metastasis (n = 13, 43.3%) was the most common etiology, followed by microvascular causes (n = 11, 36.7%), radiation-induced neuropathy (n = 2, 6.7%), and undetermined (n = 4, 13.3%). Among the 13 patients with palsies due to brain metastasis, only one (7.7%) had been in complete remission for more than 1 year. Of the remaining 17 patients with other causes, seven (41.2%) had been in complete remission of a previously diagnosed cancer for more than 1 year.Conclusions: In patients with a history of cancer, cranial nerve palsy due to brain metastasis was the most common cause, and it was more likely if the primary cancer had not been in remission for more than 1 year. Brain magnetic resonance imaging should be performed as soon as possible to confirm brain metastasis and a differential diagnosis including various other causes is also important.