Sulfonium N-chloramines were synthesized with significantly higher antibacterial efficacy than previous quaternary ammonium counterpart 1, and the highest efficacy was achieved for dodecyl chained N-chloramine 9 due to a synergistic biocidal effect.
We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG- COOH /lecithin, DSPE-PEG- COOH /DSPE-PEG- NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA–lecithin–PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.
Two types of long-chained pyridinium N-chloramines were designed and synthesised by covalent linking a N-chloramine unit and a long intact alkyl chain via varied alkylation of 3-hydroxypyridine. Preliminary antibacterial tests showed that both synthetic pyridinium N-chloramines exerted distinctively elevated biocidal efficacy in contrast to previously reported pyridinium N-chloramines that lack a long chain. Such enhanced bactericidal behaviour was probably caused by ‘synergistic’ biocidal action between the N-chloramine moiety and the long-chained pyridinium moiety.
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