Rubber friction on ice is studied both experimentally and theoretically. The friction tests involve three different rubber tread compounds and four ice surfaces exhibiting different roughness characteristics. Tests are carried out at four different ambient air temperatures ranging from À5 to À13 C, under three different nominal pressures ranging from 0.15 to 0:45 MPa, and at the sliding speed 0.65 m/s. The viscoelastic properties of all the rubber compounds are characterized using dynamic mechanical analysis. The surface topography of all ice surfaces is measured optically. This provides access to standard roughness quantities and to the surface roughness power spectra. As for modeling, we consider two important contributions to rubber friction on ice: (1) a contribution from the viscoelasticity of the rubber activated by ice asperities scratching the rubber surface and (2) an adhesive contribution from shearing the area of real contact between rubber and ice. At first, a macroscopic empirical formula for the friction coefficient is fitted to our test results, yielding a satisfactory correlation. In order to get insight into microscopic features of rubber friction on ice, we also apply the Persson rubber friction and contact mechanics theory. We discuss the role of temperature-dependent plastic smoothing of the ice surfaces and of frictional heating-induced formation of a meltwater film between rubber and ice. The elaborate model exhibits very satisfactory predictive capabilities. The study shows the importance of combining advanced testing and state-ofthe-art modeling regarding rubber friction on ice.
Purpose There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy. Methods This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. A responder was defined as a patient with ≥50% reduction in monthly seizure frequency compared with the baseline. Adverse events and discontinuation data were obtained to evaluate tolerability. Results Twenty-two patients (8 males, 14 females) aged 3.1–11.4 years (mean, 8.0±2.5 years) were included in this study. After an average of 9.2 months (range, 0.5–19 months) of follow-up, 15 patients (68%) showed a reduction in seizure frequency, including 5 patients (23%) with seizure freedom. The age at epilepsy onset was significantly lower ( P =0.048), and the duration of epilepsy was significantly longer ( P =0.019) in responders than in nonresponders. Nine patients (41%) experienced adverse events, including somnolence (23%), respiratory depression (9%), violence (4.5%), and seizure aggravation (4.5%). The most serious adverse event was respiratory depression, which required mechanical ventilation in 2 patients (9%). Eight patients (36%) discontinued perampanel due to lack of efficacy or adverse events. Three out of 4 patients (75%) who discontinued perampanel due to adverse events had an underlying medical condition. Conclusion Perampanel offers a treatment option for refractory epilepsy in children. Adjunctive treatment with perampanel requires special consideration in those with underlying medical conditions to prevent serious adverse events.
Background: Teicoplanin is used to treat serious gram-positive infections. Optimal teicoplanin trough levels are considered to be ≥ 10 μg/mL. Despite its wide use in various clinical settings, data on teicoplanin trough level in pediatric patients are limited. Therefore, the aim of this study was to investigate the therapeutic drug level monitoring of teicoplanin in Korean pediatric patients, including those with impaired renal function. Methods: A retrospective study was performed in pediatric patients (age ≤ 18 years old) who received teicoplanin from September 2014 to April 2018. The regimen included a loading dose of 10 mg/kg/dose at 12 hours' interval three times in a row, and a maintenance dose of 10 mg/kg/dose commenced at 24 hours of interval after the loading dose, with a maximum of 400 mg/dose, respectively. The first therapeutic drug levels were measured. Distribution and characteristics of trough levels in patients with decreased renal function and those with bacteremia were also assessed. Results: A total of 187 trough levels were collected from 143 patients. Hematologic and oncologic diseases were the most common underlying diseases (83.2%, n = 119). One hundred eighty trough levels were first measurements, their median value was 16.2 μg/mL (range, 2.3-100 μg/mL) and the median interval between initial teicoplanin injection and 1st trough level was 96.5 hours (range 47.6-179.3 hours). Lower steady-state levels were observed in younger age group (median, 13.5 vs. 18.0 μg/mL, P = 0.038). Median trough levels were higher in patients with decreased renal functions (P < 0.001). In addition, among eight with gram-positive bacteremia, seven of them had a favorable outcome. Conclusion: This study provides additive information on trough level monitoring of teicoplanin in children with impaired renal function and treatment effect in patients with gram-positive bacteremia. Careful monitoring for steady state trough levels of teicoplanin is warranted.
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