Validation
of recent findings of hot mitochondria in cancer cells
is critically needed, since a single fluorescent probe cannot rule
out the possibility of varied cellular uptake efficiencies. Here we
developed a ratiometric nanoprobe, named the mitochondria-targeted
thermoresponsive-gold nanoparticle (MTT-AuNP), for analyzing mitochondrial
temperatures. Results confirmed a relatively high mitochondrial temperature
in murine bladder cancer MB49 cells. High temperatures in mitochondria
might have far-reaching implications for developing mitochondria-targeted
therapeutics.
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