Objective: EGFR genetic polymorphisms have been investigated for carcinogenesis in various tumors including lung cancer. We evaluated EGFR mutations in four exons, with an emphasis on the Q787Q EGFR polymorphism in non-small-cell lung cancer. Methods: To determine the presence of the Q787Q polymorphism in patients with lung cancer, we performed direct sequencing analyses of four exons for 83 squamous cell carcinomas and 80 adenocarcinomas untreated with EGFR tyrosine kinase inhibitors. Results: The Q787Q EGFR polymorphism was more frequently detected in squamous cell carcinoma patients than in adenocarcinoma patients (24 vs. 15.9%). The group of patients with the Q787Q EGFR polymorphism included more males and heavy smokers compared with other patient groups. The presence of the Q787Q EGFR polymorphism significantly and negatively affected the overall survival rate among patients with non-small-cell carcinoma (p = 0.011), particularly those with squamous cell carcinoma (p = 0.037). Among stage I and II squamous cell carcinoma patients, those with the Q787Q EGFR polymorphism had a poor prognosis (p = 0.032). Conclusions: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II.
Purpose: Securin is a regulatory protein, which plays a central role in chromosome stability and control of the metaphase-anaphase transition and anaphase onset. Securin blocks separase/extra spindle pole bodies homolog 1 function, preventing the proteolysis of the subsequent dissociation of the chromosome. Securin is expressed at low level in most tissues, but many patient suffering epithelial neoplasms are overexpressed. The aim our study was to evaluate whether securin affects tumorigenesis and prognosis in patients of colorectal cancer. Methods: To clarify the roles of securin in colorectal tumorigenesis, its expression was examined by immunohistochemistry on a tissue microarray with its comparison with clinicopathologic parameters and prognosis survivals of the colorectal carcinomas. Results: Securin was overexpressedin 272 (76.2%) of 357 colorectal carcinomas. Overexpression of securin was correlated with gender (P= 0.060), pathologic T stage (P= 0.006) and tumor node metastasis stage (P= 0.002), but securin overexpression was not correlated with lymphovascular invasions. Securin overexpression was not correlated with 5-year survival rate by Kaplan-Miere survival model. Conclusion: Securin expression was correlated with T stage and TNM (tumor node and metastasis) stage in colorectal cancer. Our study showed a possible role for securin in colorectal tumorigenesis. These findings indicate that securin has a function of tumorigenesis with tumor enlargement, not of lymphovasculogenesis.
observation, 89% believe it is still possible to treat effectively if the CRLM grows on surveillance imaging. Conclusion: While surgical management of dCRLM varies widely, nearly all surgeons use intraoperative ultrasound and mandate recent preoperative imaging. Interestingly, nearly half of the respondents elect for observation with the belief that there remains an opportunity to re-address these lesions in the future.
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