Antibiotics are currently the main therapeutic agent for bacterial infections, but they have led to bacterial resistance, which has become a worldwide problem that needs to be addressed. The emergence of inorganic nanomaterials provides a new opportunity for the prevention and treatment of bacterial infection. With the continuous development of nanoscience, more and more inorganic nanomaterials have been used to treat bacterial infections. However, single inorganic nanoparticles (NPs) are often faced with problems such as large dosage, strong toxic and side effects, poor therapeutic effect and so on, so the combination of inorganic nano-materials and photothermal therapy (PTT) has become a promising treatment. PTT effectively avoids the problem of bacterial drug resistance, and can also reduce the dosage of inorganic nanomaterials to a certain extent, greatly improving the antibacterial effect. In this paper, we summarize several common synthesis methods of inorganic nanomaterials, and discuss the advantages and disadvantages of several typical inorganic nanomaterials which can be used in photothermal treatment of bacterial infection, such as precious metal-based nanomaterials, metal-based nanomaterials and carbon-based nanomaterials. In addition, we also analyze the future development trend of the remaining problems. We hope that these discussions will be helpful to the future research of near-infrared (NIR) photothermal conversion inorganic nanomaterials.
A photoresponsive synergistic therapy platform (Se@PDA-ICG) was constructed by loading indocyanine green on polydopamine functionalized selenium nanoparticles. It shows light response to kill bacteria and accelerates infected wound healing.
Background
Bacterial infections have always been one of the medical challenges facing mankind. Compared with conventional antibiotic therapy, photoresponsive synergistic antibacterial offers a new therapeutic modality.
Results
Herein, a photoresponsive synergistic therapeutic antibacterial platform was designed and constructed by polydopamine-functionalized selenium nanoparticles as carrier loading indocyanine green (Se@PDA-ICG). The synergistic therapeutic platform was confirmed by characterization and the antibacterial activity of Se@PDA-ICG against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was investigated. Se@PDA-ICG at a low concentration of 125 µg/mL in dark showed antibacterial rates of 14.3% and 52.7% against E. coli and S. aureus, respectively. Under 808 nm laser irradiation, the antibacterial rates against both bacteria increased to 100%. Furthermore, in the mouse wound infection model, the wound closure rate of the Se@PDA-ICG photoresponse group was 88.74% compared with the 45.8% of the control group after 8 days treatment, indicating that it could effectively kill bacteria and dramatically accelerate the wound healing process.
Conclusions
These results suggested that Se@PDA-ICG could be a promising photo-activated antibacterial candidate material for biomedical applications.
Correction for ‘Polydopamine-functionalized selenium nanoparticles as an efficient photoresponsive antibacterial platform’ by Meng Sun et al., RSC Adv., 2023, 13, 9998–10004, https://doi.org/10.1039/D2RA07737J.
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