Multimodal information processing has received considerable attention in recent years. The focus of existing research in this area has been predominantly on the use of fusion technology. In this paper, we suggest that cross-modal association can provide a new set of powerful solutions in this area. We investigate different cross-modal association methods using the linear correlation model. We also introduce a novel method for cross-modal association called Crossmodal Factor Analysis (CFA). Our earlier work on Latent Semantic Indexing (LSI) is extended for applications that use off-line supervised training. As a promising research direction and practical application of cross-modal association, cross-modal information retrieval where queries from one modality are used to search for content in another modality using low-level features is then discussed in detail. Different association methods are tested and compared using the proposed cross-modal retrieval system. All these methods achieve significant dimensionality reduction. Among them CFA gives the best retrieval performance. Finally, this paper addresses the use of cross-modal association to detect talking heads. The CFA method achieves 91.1% detection accuracy, while LSI and Canonical Correlation Analysis (CCA) achieve 66.1% and 73.9% accuracy, respectively. As shown by experiments, cross-modal association provides many useful benefits, such as robust noise resistance and effective feature selection. Compared to CCA and LSI, the proposed CFA shows several advantages in analysis performance and feature usage. Its capability in feature selection and noise resistance also makes CFA a promising tool for many multimedia analysis applications.
In this paper, we address the problem of classi®cation of continuous general audio data (GAD) for content-based retrieval, and describe a scheme that is able to classify audio segments into seven categories consisting of silence, single speaker speech, music, environmental noise, multiple speakers' speech, simultaneous speech and music, and speech and noise. We studied a total of 143 classi®cation features for their discrimination capability. Our study shows that cepstralbased features such as the Mel-frequency cepstral coe cients (MFCC) and linear prediction coe cients (LPC) provide better classi®cation accuracy compared to temporal and spectral features. To minimize the classi®cation errors near the boundaries of audio segments of di erent type in general audio data, a segmentation±pooling scheme is also proposed in this work. This scheme yields classi®cation results that are consistent with human perception. Our classi®cation system provides over 90% accuracy at a processing speed dozens of times faster than the playing rate. Ó
BackgroundNext-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features and clinical conditions could significantly affect the concordance between ctDNA and corresponding tumor tissues. Our goal was to systematically investigate the critical factors contributing to different concordance between ctDNA and corresponding tumor tissues.MethodsWe recruited two groups of IIIB or IV lung cancer patients: The standard group to evaluate the accuracy of our method and the concordance between ctDNA and tumor tissues, and the study group with various clinical conditions. We applied our unique identification (UID) indexed capturing-based sequencing (UC-Seq) to ctDNA samples, and confirm the results by Droplet digital PCR (ddPCR).ResultsConsidering mutations detected from NGS of tumor tissues as golden standard, UC-Seq achieved overall 93.6% sensitivity for SNVs and Indels, and 0.8 Pearson correlation between tumor TMB and bTMB. Efficacious treatments, long sampling date (more than 2 weeks) between tumor tissues and ctDNA and low concentrations of cfDNA (less than 9 ng/ml) could significantly decrease the concordance between ctDNA and tumor tissues. About 84% mutations showed shorter mutant fragment length than that of wild-type fragments, and the AFs of mutations could be significantly enriched in small-size ctDNA.ConclusionsIn late-stage lung cancer patients, ctDNA generally has high concordance with tumor tissues. However it could be significantly affected by three clinical conditions which could dynamically change the content of ctDNA. Moreover, the detection limit could be further extended by enriching small-size ctDNA in the preparation of samples.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4199-7) contains supplementary material, which is available to authorized users.
In contrast to the adult, fluoxetine exposure in utero induces pulmonary hypertension in the fetal rat as a result of a developmentally regulated increase in pulmonary vascular smooth muscle proliferation.
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