Hydrolysis of cellulose to high yield glucose in water remains challenging owing to the limited acidity and contact to substrate for sulfonated carbons. Herein, we report a unique sulfonated mesoporous...
The Rh/Au-catalyzed regioselective C-8/C-4 alkynylation of N-methylisoquinolone has been theoretically investigated with the aid of density functional theory (DFT) calculations. The versatile function of substrate 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) is explored in this study. In the [Cp*RhCl 2 ] 2 -catalyzed reaction, TIPS-EBX is acted as the Brønsted base to go through the self-assisted deprotonation mechanism to produce the C8alkynylation product solely. The obvious regioselectivity could be attributed to the electron effects. In contrast, due to the steric effects, the C4-alkynylation product becomes the major product by employing AuCl as the catalyst. In this reaction, the iodine(III) center in the TIPS-EBX moiety could be employed as a strong Lewis acid to activate the alkyne moiety efficiently.
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