The SCID mouse (severe combined immunodeficiency mouse) has been used as a small animal model in the analysis of human pathophysiology and preclinical experiment for many years. As the most difficult challenge faced in the research of AIDS, chronic hepatitis B and chronic hepatitis C is the lack of appropriate small animal model, researchers have always attempted to develop a series of mouse models based on the improvements of the SCID mouse. This review focuses on the developments and applications of such SCID mouse models in three types of the above chronic infectious diseases.
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