Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic protocol for the treatment of viologen poisoning. The mechanism of this new protocol is based on host-guest chemistry and involves the effective inhibition of viologen toxicity by the complexation of p-sulfonatocalix[n]arenes. NMR, ITC, and X-ray crystallography studies indicated that p-sulfonatocalix[n]arenes could form highly stable complexes with viologens. Electrochemical results showed that the highly effective binding could induce the reduction potentials of viologens to shift to more negative values. Further studies in mice showed that the ingestion of p-sulfonatocalix[n]arenes significantly decreased the mortality rate of viologen-poisoned mice with lung and liver protection. As a result, p-sulfonatocalix[n]arenes may have potential application in the clinical treatment of viologen poisoning.
Traditional topology optimization is usually carried out with approaches where structural boundaries are represented in an implicit way. The aim of the present paper is to develop a topology optimization framework where both the shape and topology of a structure can be obtained simultaneously through an explicit boundary description and evolution. To this end, B-spline curves are used to describe the boundaries of moving morphable components (MMCs) or moving morphable voids (MMVs) in the structure and some special techniques are developed to preserve the smoothness of the structural boundary when topological change occurs. Numerical examples show that optimal designs with smooth structural boundaries can be obtained successfully with the use of the proposed approach.
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