No abstract

A new efficient method for the synthesis of geometrically pure (E)-alkenes from (Z)-alkenes is described. The reaction of aryl- or alkyl-substituted (Z)-alkenes with tributyltin hydride and triethylamine in the presence of a catalytic amount of palladium acetate afforded the corresponding (E)-alkenes in good yields.

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The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described.

Synthesis of 3-(Diarylmethylene)oxindoles via a Palladium-Catalyzed One-PotReaction: Sonogashira-Heck-Suzuki-Miyaura Combined Reaction. -A Pd-catalyzed cascade reaction consisting of an intramolecular Heck-type cyclization and subsequent Suzuki-Miyaura coupling is achieved under typical Sonogashira reaction conditions to yield diarylmethylene indolones (IV). Silver salts as an additive for the second step, the Suzuki-Miyaura reaction, allow the formation of unsymmetrical diaryl products with enhanced selectivity. -(DONG, G. R.; PARK, S.; LEE, D.; SHIN, K. J.; SEO*, J. H.; Synlett 24 (2013) 15, 1993-1997, http://dx.