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I958 and the concentration and type of acceptor amine has been studied. 4. The manometric method has been used to demonstrate that heteropyrithiamine, quinilinothiamine and possibly oxythiamine are thiaminase substrates. 5. The effect of several structural analogues of thiamine on bracken thiaminase has been studied and it is shown that 3-(o-aminobenzyl)-4-methylthiazolium chloride is a powerful but non-competitive inhibitor. 6. Conditions are described under which the rate of evolution of carbon dioxide is directly proportional to the amount of bracken-thiaminase preparation present. It is suggested that the manometric method could be used for estimating thiaminase activity.

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