2The immunogenicity and reactogenicity of inactivated influenza A/New Jersey/76 (Hsw1N1) whole-virus vaccine administered intradermally (40 chick cell-agglutinating units/0.1-ml dose) and intramuscularly (im; 200 chick cell-agglutinating units/0.5-ml dose) to human adults were evaluated. Among 18-24-year-old persons initially free of detectable antibody, intradermal vaccination induced lower titers of hemagglutination-inhibiting antibodies than did im vaccination, and a sequence of intradermal and im vaccinations did not offer any serologic advantage over one im dose. In contrast, persons over the age of 24 who initially lacked detectable antibody had as good a serologic response to intradermal vaccination as to im vaccination. Among individuals who had antibody before vaccination, immunization by either route induced greater increases in titers of hemagglutination-inhibiting antibody than occurred in initially antibody-negative persons, even when the latter were given two doses of vaccine. Somewhat fewer systemic reactions occurred after intradermal than after im vaccination, but the intradermal route was associated with local reactions in almost all vaccinees and with some residual pigmentary changes. These results suggest that intradermal vaccination should be used only in very selected circumstances.
JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. This content downloaded from 194.27.18.18 on Wed, 30 Dec 2015 15:45:00 UTC All use subject to JSTOR Terms and Conditions GEOGRAPHICAL REVIEWS GEOGRAPHICAL REVIEWS crops, and extent and dimensions of terraces. The diversity of terrace forms is clearly illustrated by ninety-two photographs, plus cross-sectional diagrams and sketches of field patterns. Hemispheric and regional maps show the distribution of terracing in the Americas from Colorado to central Chile; locations are indicated by known towns where terraces have been observed or reported. A large appendix provides a table listing sites with terraces and indicating form, use, and authority for each. The comprehensive bibliography contains some 1,200 items. The text is brief, with more than half the study consisting of graphics, appendix, and bibliography.In addition to the regional descriptions, Donkin discusses traditional field implements, archaeological dating of terraces, terrace classification and functions, and associations with climate and terrain. He believes the oldest terraces date to circa 700-500 B.C. in both central Mexico and the central Andes, although Patrick has recently suggested in an unpublished pa-
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