The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed.
The percutaneous declotting of forearm fistulae by manual catheter-directed thrombo-aspiration was effective in more than 90% of cases and yielded 50% primary and 80% secondary patency rates at one year. The results were poorer in upper arm fistulae. The need for maintenance reinterventions was three times smaller in forearm fistulae than in upper arm fistulae and grafts.
SUMMARY Juvenile crickets suffer high rates of mortality by natural predators that they can detect using extremely sensitive air-sensing filiform hairs located on their cerci. Although a huge amount of knowledge has accumulated on the physiology, the neurobiology and the biomechanics of this sensory system in adults, the morphological and functional aspects of air sensing have not been as well studied in earlier life history stages. Using scanning electronic microscopy, we performed a survey of all cercal filiform hairs in seven instars of the wood cricket (Nemobius sylvestris). Statistical analyses allowed us to quantify profound changes in the number, the length and the distribution of cercal hairs during development. Of particular importance,we found a fivefold increase in hair number and the development of a bimodal length-frequency distribution of cercal hairs from the second instar onwards. Based on theoretical estimations of filiform hair population coding, we found that the cercal system is functional for a wide range of frequencies of biologically relevant oscillatory flows, even from the first instar. As the cricket develops, the overall sensitivity of the cercal system increases as a result of the appearance of new hairs, but the value of the best tuned frequency remains fixed between 150 and 180 Hz after the second instar. These frequencies nicely match those emitted by natural flying predators, suggesting that the development of the cercal array of hairs may have evolved in response to such signals.
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