Objective: This study aimed at examining the vulnerability of Central Africa to the Covid-19 pandemic. Methods: Demographic, health and socio-economic indicators were used to describe the vulnerability. Results: According to demographic indicators, populations appear younger than in Europe, Asia and North America, where evidence showed a higher lethality of Covid-19 and a higher frequency of hospitalization among the elderly. This highlights the protective effect of the age structure of the Central African populations. There is a significant vulnerability of their populations resulting from high morbidity and a considerable deficit in health care. Poverty indicators are not in their favour for a sustainable implementation of effective pandemic control measures. Very low literacy rates in some countries, misinformation and belief in conspiracy theory could affect the community involvement in the response. Several countries are weakened by other humanitarian crises, including; conflicts and other epidemics. The early easing in lockdown restrictions in certain countries could worsen the situation. Conclusion: This Sub-region, where the largest proportion of the population lives in poverty, poor sanitary conditions, conflicts and humanitarian crises, the questions of standards of prevention could appear to them as luxurious idea relegated to the background. Central African Countries need financial and logistic support for a sustainable effective response. These observations could be easily extrapolated to other Sub-Saharan sub-regions.
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