Migration of an entire one-piece shunt into the lateral ventricle of a six-month-old boy is reported. This is a rare complication in this kind of shunt, and has not previously been reported.

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Virtual screening through molecular docking can be translated into an optimization problem, which can be tackled with metaheuristic methods. The interaction between two chemical compounds (typically a protein, enzyme or receptor, and a small molecule, or ligand) is calculated by using highly computationally demanding scoring functions that are computed at several binding spots located throughout the protein surface. This paper introduces METADOCK, a novel molecular docking methodology based on parameterized and parallel metaheuristics and designed to leverage heterogeneous computers based on heterogeneous architectures. The application decides the optimization technique at running time by setting a configuration schema. Our proposed solution finds a good workload balance via dynamic assignment of jobs to heterogeneous resources which perform independent metaheuristic executions when computing different molecular interactions required by the scoring functions in use. A cooperative scheduling of jobs optimizes the quality of the solution and the overall performance of the simulation, so opening a new path for further developments of virtual screening methods on high-performance contemporary heterogeneous platforms.

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Data Envelopment Analysis (DEA) is a non-parametric technique for estimating the technical efficiency of a set of Decision Making Units (DMUs) from a database consisting of inputs and outputs. This paper studies DEA models based on maximizing technical efficiency, which aim to determine the least distance from the evaluated DMU to the production frontier. Usually, these models have been solved through unsatisfactory methods used for combinatorial NP-hard problems. Here, the problem is approached by metaheuristic techniques and the solutions are compared with those of the methodology based on the determination of all the facets of the frontier in DEA. The use of metaheuristics provides solutions close to the optimum with low execution time.