Summary Objective To assess the prevalence of and characteristics associated with current smoking in an Asian HIV-positive cohort, calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD), and myocardial infarction (MI), and identify the impact that simulated interventions may have. Methods Logistic regression analysis distinguished associated characteristics. Five-year predictive risks of CVD, CHD, MIs and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results Smoking status data were collected from 4,274 participants and 1,496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2% vs. 19.9%). Characteristics associated with current smoking included being ≥50 years compared to 30–39 years (OR, 0.65; 95% confidence interval [CI], 0.51–0.83), HIV exposure through injection drug use compared to heterosexual exposure (OR, 3.03; CI, 2.25–4.07), and receiving ART at study sites in Singapore, South Korea, Malaysia, Japan, and Vietnamese sites in comparison to Thailand (all odds ratios >2). Alternatively, females were less likely to smoke than males (OR, 0.11; CI, 0.08–0.14). In simulated interventions smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of five-year MI risk. Conclusion Multiple interventions could reduce CVD, CHD, and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.