Molecular fluorophores based on N,C-chelate, four-coordinate organoborons exhibit tunable solid-state emission colors that cover the whole visible region from blue to red. The emission color can be tuned through the substituents on either quinolines or the boron center.

Oxidative intramolecular 1,2-amino-oxygenation reactions, combining gold(I)/gold(III) catalysis, is reported. The reaction provides efficient access to a structurally unique ionic pyridinium-oxazole dyad with tunable emission wavelengths. The application of these fluorophores as potential biomarkers has been investigated.

The reaction of [RuCl2(η6‐p‐cymene)]2 with indole based thiosemicarbazone ligands (L1‐L3) yielded monometallic ruthenium(II) complexes, [RuCl(η6‐p‐cymene)(L)]Cl (1–3). The complexes were characterized by analytical and various spectroscopic (UV‐visible, FT‐IR, 1H & 13C NMR and mass) tools. The solid state structure of complex 2 determined by single crystal X‐ray diffraction analysis showed a piano stool geometry around the metal. The Ru(II)‐p‐cymene complexes with N‐substituted thiosemicarbazone were evaluated for their potential to inhibit aggregation of Aβ peptide and associated cytotoxicity. Results of turbidity assay revealed that complexes 1 and 2 exhibited 70 and 60% inhibition of Aβ peptide aggregation respectively. All the tested compounds were nontoxic to neuronal cells. Interestingly complexes 1 and 2 showed attenuation of Aβ induced cytotoxicity due to flexible alkyl substitution at terminal nitrogen of thiosemicarbazone moiety.

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