Artificial water channels mimicking natural aquaporins (AQPs) can be used for selective and fast transport of water.H ere,w eq uantify the transport performances of peralkyl-carboxylate-pillar[5]arenes dimers in bilayer membranes.T hey can transport % 10 7 water molecules/channel/ second, within one order of magnitude of the transport rates of AQPs,rejecting Na + and K + cations.The dimers have atubular structure,s uperposing pillar[5]arene pores of 5 diameter with twisted carboxy-phenyl pores of 2.8 diameter.T his biomimetic platform, with variable pore dimensions within the same structure,o ffers sizer estriction reminiscent of natural proteins.I ta llows water molecules to selectively transit and prevents bigger hydrated cations from passing through the 2.8 pore.M olecular simulations prove that dimeric or multimeric honeycomb aggregates are stable in the membrane and form water pathwayst hrough the bilayer.O ver time, asignificant shift of the upper vs.lower layer occurs initiating new unexpected water permeation events through toroidal pores.

Artificial water channels mimicking natural aquaporins (AQPs) can be used for selective and fast transport of water.H ere,w eq uantify the transport performances of peralkyl-carboxylate-pillar[5]arenes dimers in bilayer membranes.T hey can transport % 10 7 water molecules/channel/ second, within one order of magnitude of the transport rates of AQPs,rejecting Na + and K + cations.The dimers have atubular structure,s uperposing pillar[5]arene pores of 5 diameter with twisted carboxy-phenyl pores of 2.8 diameter.T his biomimetic platform, with variable pore dimensions within the same structure,o ffers sizer estriction reminiscent of natural proteins.I ta llows water molecules to selectively transit and prevents bigger hydrated cations from passing through the 2.8 pore.M olecular simulations prove that dimeric or multimeric honeycomb aggregates are stable in the membrane and form water pathwayst hrough the bilayer.O ver time, asignificant shift of the upper vs.lower layer occurs initiating new unexpected water permeation events through toroidal pores.