To date, in the context of the COVID 19 pandemic, there are rumors and speculations about the consequences of the infection, as well as a concern on growing cancer risk due to vaccines and vaccination. In this study we reviewed the concepts of the viral action on cancer development and analyzed the data on the possibility of the malignant effect of the SARS-CoV-2 virus on cells. Analysis of the literature data showed that SARS-CoV-2 damages cells, like other viruses, but does not lead to their mutations. There are no changes in DNA, there is only misregulation of repression and expression of the genome, a perversion of signaling intercellular interactions that disrupt the mechanisms of differentiation and specialization of cells. The need of viruses to multiply in cambial cells of tissues contributes to the induction of their proliferation and the lack of specialization. Thus, the available information on the cytopathic effects caused by viruses in cells infected with COVID-19 does not yet provide information on the malignant effect of SARS-CoV-2. Our study is aimed at collecting and analyzing data that are necessary for planning effective treatment of patients with COVID 19 and predicting outcomes in the long term after the disease.
A study of the diagnostic value of tissue eosinophil infiltration in the structure of polyps of the human gastrointestinal tract and surrounding tissues was carried out. We investigated intestinal biopsies from 189 patients aged 40–90 years with polyps, cancer, metastases. This retrospective study allows us to note the possibility of using eosinophils in the development of criteria for early malignancy and a promising outcome of neoplasms in the mucous membrane. Eosinophils are important players in intercellular interactions within the polyp structure and the tissues around it. The complete absence of eosinophils in the tissue of malignant polyps indicates the malignancy of the neoplasm. We revealed relationship between apoptosis and eosinophilic infiltration; both of them affect the outcome and prognosis of polyp development. Apoptosis induction by eosinophils and programmed cambium necrosis in tumor progression need to be further researched.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.