[reaction: see text] The alkoxide-directed hydrogenation shown is reported as a key step in a concise synthesis of a fully functionalized precursor to the C29-C40 F/G sector of pectenotoxin-2.
[reaction: see text] Practical asymmetric synthesis of aldehyde 2 and tetrazolyl sulfone 3 has allowed for their coupling via Julia olefination to generate 32 as a single product. This substance possesses the entire carbon backbone of the A-E substructure of pectenotoxin-2.
Photoreactive cross-linking reagents that simultaneously contain a trifluoromethyldiazirine and an o-nitrobenzyl groups were synthesized for the first time. Photochemical properties of the reagents were studied, and the possibility of separate activation of the diazirine group and o-nitrobenzyl linker was shown.
Other bioactive products U 1300 Alkoxide Precoordination to Rhodium Enables Stereodirected Catalytic Hydrogenation of a Dihydrofuranol Precursor of the C29-40 F/G Sector of Pectenotoxin-2. -(PENG, X.; BONDAR, D.; PAQUETTE*, L. A.; Tetrahedron 60 (2004) 43, 9589-9598; Evans Chem. Lab., Ohio State Univ., Columbus, OH 43210, USA; Eng.) -Klein 05-223
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