The results are presented on the study of the damage of melanin granules contained in ex-vivo animal skin specimens under a series of single Nd:glass laser pulses of nanosecond duration, with intensity I ~ 10 8 W/cm 2 . The mechanism responsible for tissue damage at the given conditions is shown to be a selective photodisruption occurring due to preferential energy absorption by endogenic skin pigment. For such a complicated multicomponent structure as biotissue comprising substructures inhomogeneously distributed in the bulk of it and differing in physical and chemical properties, such a parameter as volume energy density becomes a decisive one for tissue damage. When its magnitude reaches the damage threshold value within the absorption loci it breaks whereas the surrounding tissue remains undisturbed.
Under high-intensity laser pulses the morphology and size of the crater induced in biotissue depends both on biotissue properties and on irradiation conditions. The objective ofthis study is to correlate the wound morphology and patterns of microdestruction with the mechanisms of interaction. Along with the regime of superficial layerwise evaporation of tissue induced by CO2 medical, or selective photocoagulation induced by copper vapor lasers, the present work describes the regime of bulk selective damage of coloration centers that are irregularly distributed in the deep ofthe tissue. Photo induced disruption is the mechanism responsible for it.
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