Background: Pancratistatin (PST), a compound extracted from an Amaryllidaceae (AMD) family plant, has been shown to specifically induce apoptosis in cancer cells with no/minimal toxic effect on normal cells. A systematic synthetic approach has indicated that the minimum cytotoxic pharmacophore comprises the trans-fused b/c-ring system containing the 2, 3, 4-triol unit in the Cring. To further explore the structure-activity relationship of this group of compounds we have investigated the anti-cancer efficacy and specificity of two PST-related natural compounds, AMD4 and AMD5. Both of these compounds lack the polyhydroxylated lycorane element of PST instead having a methoxy-substuituted crinane skeleton.
Background: This study explored the key physical and social factors within the home environment that influence the participation of children with an ASD in home activities. Method: Step 1 used a correlational research design to identify relationships between the home environment and participation patterns of children with ASD. Twenty-two children, ages 3 to 6 years, with a diagnosis of ASD participated.
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