Until now, there has been progress in the treatment of ovarian cancer, but ovarian carcinoma is still a cause of high mortality. Various factors have been known to be associated with a poor prognosis, such as the absence of symptoms, lack of an effective screening tool, diagnosis of the disease that was only detected after an advanced stage, high recurrence of disease resistant to chemotherapy. There are more than 70% of cases detected in advanced stage, with long-term survival of only 15-30%; while those detected in early stages, the survival reaches 90%. The recurrence risk of IIIC stage disease is as high as 40% -50%. However, there is a small group of patients who can recover after standard therapy. There is variability in the recurrence-free period and survival, so it is difficult to predict the outcome with certainty. Ovarian cancer patients with the same characteristics can show a different prognosis, related to high molecular heterogeneity of tumor genetics. We report a rare case that is a 56-year-old woman who has experienced a 5year free disease after complete remission after standard chemotherapy from stage IIIC ovarian cancer. The disease-free period of up to 5 years after therapy may be related to factors that can be predictors of prognosis, such as age at diagnosis, body mass index, physical performance, cancer cell biology, and the success of surgical response and chemotherapy in these patients.

Nasopharyngeal cancer (NPC) is a type of cancer in Southeast Asia, with 30-80 cases annually per 10,000 population. Based on the data, about 80% of patients with advanced-stage are diagnosed first, while 20% develop metastases after therapy. Prognostic assessment is essential for the optimization of treatment. Malnutrition is one of the consequences of decreased response to treatment, quality of life, and survival. The patient's albumin determines nutrition. This study was a retrospective study to evaluate the ability of pre-therapy albumin levels to predict long-term mortality in 227 NPC patients at Dr. Sardjito Hospital. Univariate analysis identified albumin as a statistically significant predictive factor for survival (P 0.021). Albumin (ALB) 3.50 was significantly associated with shorter survival. Median Overall Survival showed (OS) ± SE ALB 3.50 vs. ALB 3.50: 9.40 ± 2.56 vs. 17.63 ± 1.51 months, P 0.021, Hazard Ratio (HR) 1.368; 95% CI (1.049–1.783). However, multivariate analysis showed low serum albumin levels before therapy on survival in NPC patients (P 0.778, HR 1.050, 95% CI (0.75–1.469). Treatment was identified as the only independent predictive factor for survival. Albumin before therapy was a potential predictive biomarker to evaluate survival in NPC patients but not an independent predictor.

Toxoplasmosis is caused by infection with the protozoan Toxoplasma gondii. Congenital Toxoplasmosis is an infection resulting from the transplasental passage of the parasites from infected mother to the fetus. An acute infection in pregnant women associated with a range of outcomes from subclinical infection to intra uterine death.Early diagnosis is important to make decision, therapy or abortion. At present, prosedur diagnostic of congenital toxoplasmosis uses conventional methode especially serological test,but the conventional methode is time consuming, and has high risk. PCR amniotic fluid is one methode to make dignostic of conegenital toxoplasmosis. This is very sensitif and rapid (24 hours) and safer than serological tes of the fetalblood.PCR can be done from 15 week after gestation.

Indonesia adalah salah satu negara dengan penderita diabetes terbanyak nomor 4 di dunia dengan jumlah 8,4 juta orang. Diabetes melitus memiliki komplikasi yang dapat menyebabkan kecacatan serta kematian. Penyakit DM (DiabbSetes Melitus) dapat dicegah dengan pola hidup yang sehat. Masyarakat perlu diberikan edukasi untuk memiliki pola hidup yang baik sehingga terhindar dari DM. Pos Binaan Terpadu (Posbindu) sebagai Mitra kegiatan, memiliki potensi untuk aktif melakukan promosi dan prevensi Diabetes melitus  di masyarakat. Mengikutsertakan pengurus Posbindu dalam meningkatkan derajat kesehatan masyarakat adalah sebuah upaya yang harus dilakukan. Program “Kader Remaja Sehat Waspada Diabetes melitus” bertujuan meningkatkan pengetahuan dan keterampilan melakukan promosi pola hidup sehat dan mencegah DM.   Metode kegiatan pengabdian kepada masyarakat ini adalah pelatihan yang terdiri atas ceramah, diskusi dua arah dan bermain peran, dilanjutkan dengan penugasan di lapangan. Peserta adalah 30 pengurus Posbindu wilayah Tamantirto, Kasihan, Bantul sebagai wilayah yang dekat dengan kampus UMY, yang termasuk dalam salah satu wilayah binaan dan tempat pendidikan mahasiswa FKIK UMY. Kegiatan dilaksanakan 1 hari dan melibatkan tim pengabdian sebagai narasumber, serta pengurus Posbindu. Kegiatan ini menggunakan modul yang dibuat tim pengabdian. Luaran program adalah modul, naskah publikasi ilmiah, dan publikasi populer di media massa.

cisplatin 40 mg/m2) for 6 weeks along with Radiotherapy (IMRT). The QOL questioner was a part of dissertation thesis was used for analysis along with clinical case records for adverse events, grade, survival and time with good QOL. Results: A total of 72 patients were analyzed. The objective response rate was significantly higher in the Nimotuzumab group than in the control group in the intent-totreat population (88% versus 64.5%; P ¼ 0.04). No significant differences in median progression-free survival and overall survival were observed. Nimotuzimab had maximum TWIST score of 567 þ 245 (Meanþ SD) days and better overall QOL improvement 4.8 þ 1.2 compared to the chemo arm [465 þ 189 days and QOL improvement of 3.2 þ 1.5 points]. Conclusions: Based on the results of this retrospective analysis, Nimotuzumab weekly as single agent appears as an attractive alternative regimen for patients with HNSCC receiving definitive Radiotherapy and had better QOL and TWIST. A prospective study was planned and submitted to the local ethics committee based on above results to validate these results. If the trends are proven, this could be a choice with patients having borderline renal function and poor performance status.