Primary carcinoma of breast is common but breast is a rare site of metastasis and metastases from extramammary sites are even rarer. Metastasis to breast from rectal carcinoma is very unusual and till now 19 cases of breast secondaries from colorectal carcinoma have been reported in literature which include 14 cases where the primary site was colon and remaining 5 were from the rectum. Here the authors report a case of adenocarcinoma anorectum who had completed treatment and after 4 months developed a lump in her left breast which was metastatic. Metastatic lesions of breast are usually part of a widely disseminated disease but this case presented as a solitary breast metastasis which mimicked as second primary cancer of the breast.
Background: Cancer has emerged as huge epidemic over past two decades. There is a declining trend in the incidence of cervical cancer in the western world on the contrary in India we have observed that this disease is a great menace to a women’s health and is showing rising trend. Within the country there is wide range of variation in demography and epidemiology. There is lack of published data available on epidemiology such as age, incidence, burden, compliance of patients having cervical cancer in Uttar Pradesh.
Aims and Objectives: Current study aims to gather the evidence to understand the pattern of cervical cancer burden in the community and to find out the lacunae in the treatment delivery and receiving end.
Materials and Methods: A retrospective study was conducted on patients of cancer cervix visiting OPD of department of radiation oncology. The study comprised retrieval of medical records for different variables like age, stage, district etc and analysing it to understand the presentation and burden of disease.
Results: A total of 470 patients were studied for their epidemiology. Majority of patients were from Lucknow (78) and its nearby districts. Out of 75 districts of Uttar Pradesh, patients from 38 different districts had come to seek radiation treatment which is almost half of the Uttar Pradesh. Majority of patients in study were women in their 5th& 6th decade. The most common stage of diagnosis was II B. On histopathological evaluation most common variant found was squamous cell carcinoma with moderate differentiation 26.38%.
Conclusion: Our study highlights lack of resources in Uttar Pradesh as patients had travelled from peripheral districts to seek treatment, which lead to frequent treatment breaks and poor compliance for follow up.
Abstract:Head and Neck cancer is generally referred as squamous cell carcinoma of Head and Neck and are located at the oral or nasal cavity. It has been one of the leading cause of death around the globe and has significantly increased epidemiological growth and rate of mortality over the last three decades. A significant subset of the 600,000 annual cases of HNSCC includes approximately 85,000 HPV associated (oropharyngeal) tumors, which means that the head and neck region is the second most common HPV+ tumor site. In 90% of the HPV associated tumors, HPV16 detection can be seen. The objective of the proposed study is to evaluate the effects of chemoradiotherapy and its toxicity profile for the treatment of HPV negative and HPV positive carcinomas. In a case-control study, 100 patients were enrolled and grouped into two groups with HPV negative and HPV positive carcinogenic tumor in the ratio of 50:50. All the patients are exposed to the treatment with concurrent chemoradiotherapy and radiotherapy. From the study, it can be concluded that HPV-positive tumors have less cumulative exposure to multiple risk factors (tobacco chewing, alcohol, smoking). The association of tumor HPV status with treatment response observed in our study showed a trend of better treatment outcome, consistent in the design and analysis of current and future clinical trials of treatments for head and neck cancer patients.
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