Kanker serviks merupakan pembunuh wanita nomor satu di Indonesia dengan angka kejadian 50% dari 15.000 kasus penderita meninggal dunia. Penyebab utama dari kanker serviks ini adalah HPV (Human Papilloma Virus) serta beberapa faktor resiko lain. Pencegahan primer kanker serviks dapat dilakukan dengan vaksinasi HPV. Pengetahuan tentang kanker serviks masih rendah sehingga hal ini mempengaruhi keyakinan remaja putri dalam melakukan vaksinasi HPV. Penelitian ini bertujuan untuk menganalisis profil pengetahuan dan keyakinan vaksinasi HPV pada mahasiswi di Universitas Airlangga Surabaya dengan menggunakan teori Health Belief Model (HBM). Metode pengambilan sampel yang digunakan adalah kuota non random sampling sehingga digunakan sejumlah 120 sampel yang berstatus mahasiswi dari fakultas kesehatan dan non kesehatan di Universitas Airlangga Surabaya. Sebanyak 70,8% mahasiswi dikategorikan menjadi kelompok dengan nilai pengetahuan yang tinggi, namun pengetahuan tidak signifikan mempengaruhi niat untuk melakukan vaksinasi HPV. Pada teori HBM, keyakinan responden untuk melakukan vaksinasi HPV sebanyak 90,8% memiliki persepsi yang tinggi terhadap persepsi keseriusan dan 92,5% terhadap persepsi manfaat yang didapatkan setelah melakukan vaksinasi HPV. Adanya dukungan keluarga menunjukkan hubungan yang signifikan mempengaruhi niat untuk melakukan vaksinasi HPV (p<0,05). Maka, upaya peningkatan pengetahuan dan keyakinan perlu dilakukan untuk mahasiswi beserta keluarga agar niat melakukan vaksinasi HPV meningkat.
BackgroundNon-Hodgkin lymphoma (NHL) is a large group of primary malignancies of solid lymphoid tissue. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL. DLBCL has an aggressive natural history but responds well to chemotherapy. The objective of this study was to review the use of chemotherapy, identify its side effects, and examine the response to chemotherapy in patients with NHL at Dr. Soetomo General Hospital.MethodsThis study was a retrospective observational study using secondary data obtained from patients’ medical records from 2016 to 2018. Demographic data (age, sex), clinical characteristics, chemotherapy regimens, side effects of chemotherapy, and response to chemotherapy were recorded.ResultsResults revealed that of the 43 patients (age ranged from 21 to 80 years) who were included in this study, the prevalence of DLBCL was higher in male patients (74%) and about 44% patients were at stage III. R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine/oncovin, prednisone) (53%) was the most used chemotherapy regimen in this study. A total of 65% of patients showed good responses and 35% showed no response to the therapy. The most common side effect was myelosuppression, including 25% and 8% of the patients having anemia and leukopenia, respectively.ConclusionsR-CHOP is the most used regimen. Most of patients with NHL have a complete response and the predominant side effect is anemia.
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