offspring (5-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion tensor imaging for apparent diffusion coefficient (ADC) was used to assess white and gray matter injury and were analyzed in 3 dimensions (MD, AD and RD). RESULTS: Offspring of LPS-treated dams exhibited significantly increased MD, AD and RD levels in white and gray matter (e.g., thalamus, amygdale, visual cortex, corpus callosum, hypothalamus) consistent with cerebral injury. In contrast, offspring of NAC-treated LPS dams demonstrated, in most regions reduced MD, AD and RD levels, similar to the saline group. CONCLUSION: Maternal NAC treatment following maternal inflammation significantly reduced evidence of neonatal brain injury. These studies suggest that maternal NAC therapy may be effective in human deliveries associated with maternal/fetal inflammation such as preterm rupture of membranes and chorioamnionitis.
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