Aim: To discuss the effect of the combination of neoadjuvant intra-arterial chemotherapy by subcutaneous implantable delivery system (SIDS) and Traditional Chinese Medicine (TCM) in treatment of malignant bone and soft tissue tumors. Method: from August 2001 to February 2016, applying neoadjuvant intra-arterial chemotherapy by SIDS combined with Traditional Chinese Medicine to 148 patients with malignant bone and soft tissue tumors.Results: based on clinical symptoms, videos and laboratory tests data collected after patients have received the combined treatment, in reference to the Response Evaluation Criteria in Solid Tumors (RECIST) of the National Cancer Institute (NCI), we observed 9 patients went into complete response (CR), 120 patients went into partial response (PR), RR reached 87.2% and DCR reached 100%. We observed side effects, including Myelosuppression. Leucopenia of grade 1 or 2 occurred on 46 patients (31.08%), leucopenia of grade 3 or 4 occurred on 15 patients (10.13%), thrombocytopenia of grade 1 or 2 occurred on 22 patients (14.08%), and thrombocytopenia of grade 3 or 4 occurred on 3 patients (2.03%). Hair loss occurred on all 148 patients (100%). Myalgias or arthralgias occurred on 24 patients (16.22%). Liver injury of grade 1 or 2 occurred on 6 patients (4.05%). Gastrointestinal reactions of grade 1 or 2 occurred on 16 patients (10.81%). Conclusion:In treatment of malignant bone and soft tissue tumors, intra-arterial chemotherapy by SIDS combined with TCM can alleviate side effects or untoward effects like gastrointestinal reactions, myelosuppression, reduce damages to heart, liver, kidney and urinary system, and strengthen immune system, creating a synergistic effect.
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