We applied descriptive statistics, Pearson's correlation coefficients, and multiple linear regression analyses with SPSS 22 program. Results: A positive correlation was shown between acculturative stress and depression and a negative correlation was found between acculturative stress and quality of life. Significant factor associated with depression was acculturative stress. Significant factors associated with quality of life were acculturative stress and social support. Conclusion: Our study findings assist nurses to improve the quality of mental health services for Indonesian migrant workers by providing important information such as contact information for health services and counseling and to guide future studies on mental health issues among the population.