Melghat means "meeting of ghats" region well known for "Melghat Tiger Reserve (MTR)" located in the north-western compact block of Amravati district in Maharashtra state, India. This literature review aimed to compile and document the herbal remedies for Sexually Transmitted Infections (STIs) as Gonorrhoea, anti-HIV Leucorrhoea, Sexual Transmitted Diseases (STDs), and Syphilis in Melghat region. A total of 167 medicinal plant species from Melghat distributed among 137 genera, and 66 families have complied for Gonorrhea (103), Syphilis (85), Leucorrhoea (84), anti-HIV (10), and STD (01). Plant families like Lythraceae (17 species), Malvaceae (11 species), Moraceae (8 species), Euphorbiaceae (8 species), Acanthaceae (6 species), Amaranthaceae (6 species), Verbenaceae (6 species), were most frequently occurred in the study. Trees represented 34.13% of species, followed by Herbs (32.33%), Shrubs (20.95%), Climbers (10.17%), Grasses (1.19%), Orchids (0.59%) and Aquatic (0.59%). Leaves were the most commonly used plant parts; it accounts 19% followed by roots (18%), whole plant (13%), bark (13%), seeds (7%), fruits (6%), stem (5%), flowers (5%), etc. Curated data presented as botanical names, families, local names, habitat, floristic area (in Melghat), ailments, part used with relevant ethnobotanical citations were documented and thus offers scope for researchers engaged in herbal drug discovery and development.
Bronchitis is among the top 10 conditions for which patients look for medication. The expanding burden of chronic infections is a specific risk in developing countries. The current review focus on medicinal plants from the Melghat region used to cure Bronchitis. A total of 118 medicinal plant species from Melghat flora distributed among 104 genera and 53 families have complied for Bronchitis. The most frequently reported plant families were Asteraceae ( 14), followed by Euphorbiaceae (07), Malvaceae (07), Cucurbitaceae (06), Solanaceae (05), Verbenaceae (05), Asclepiadaceae (04), Asteraceae (04), etc. in this study. Out of 118 species reviewed, Herbs represented 31% of species, followed by Trees (30%), Shrubs (26%), Climbers (10%), and Orchids (3%). The most commonly used plant part in ailments was Leaves (24%), followed by Whole plant (19%), Bark (14%), Roots (13%), Fruits (8%), Seeds (8%), Flowers (3%), etc. Curated data presented as plant's botanical name, plant's family, habit, ailments, and part in use with relevant traditional, folk, and ethnobotanical uses patterns with cross citations. This review offers scope for the researchers engaged in drug discovery and development.
India ranks twelfth in the world for the use of pesticides. Exposure to pesticides causes tremendous health effects in people as well as in the environment. But the effect can be controlled when it is handled properly. The baseline survey was conducted to know the awareness status of the farmer, the hazardous effect faced, and the culprit spray responsible for mishaps. The various districts of Tamil Nadu, Telangana, Andhra Pradesh, Karnataka and the Union territory, Puducherry were under the survey area. The chi-square value (32.9938) suggests that there is a strong bearing between the awareness status of the farmer and the farmers undertaking safety measures. The toxicity information provided by the cide-seller is negatively correlated with farmers undertaking safety measures (r= -0.0382). There is no association was found between pre-incidence health issues and causalities (chi-square value= 151.9). The five culprit sprays such as Methoxychlor, Profenofos, Glyphosate, Diafenthiuron and Imidacloprid were selected for further study. These chemicals were docked against the target proteins. The target protein can be blended on the mask to trap the culprit spray. This would prevent the entry of pesticides into the respiratory tract of farmers and thereby prevent the mishaps.
For farmers, pesticides and insecticides are both allies and enemies. The long-term risks they generate can have significant adverse effects on farmers. In order to avoid pests and insects, the application of these chemicals in the field is also important. In the recent years, serious attention has been paid to the harmful effects of pesticides on the environment and human health by the public authorities. It is necessary for farmers to wear protective equipment in this condition to avoid the inhalation as well as absorption of these chemicals (by skin). These chemicals cause have side effects ranging from nausea, headache, temporary blindness to adverse health conditions like permanent blindness, respiratory disorder, nervous system problem, and cancer. A survey was conducted in the western region of India where 30 chemicals were auditioned among which malathione, pyrethroids and cyhalothrin got selected for further progress. Upon docking these chemicals with neutrophil elastase, cholestrerly ester transfer, G alpha, β-arrestin proteins. We found that these chemicals showed affinity with a high binding interaction towards the aromatic amino acids residues that can form H-bonds with a higher binding interaction. Therefore, from our in-silico findings we hypothesize that peptide matrix will be a good candidate for preparing blended masks to entrap the hazardous chemicals from the sprays.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.