Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide, with a prevalence of 15%-30% in Western populations. Non-alcoholic fatty liver disease (NAFLD) has emerged as the most important cause of chronic liver disease related to the increase in incidence of obesity and diabetes mellitus type II in the population. Aim of the Work To predict nonalcholic steatohepatitis in patient with NAFLD through measurement of interleukin 6 to prevent progression of the disease into liver cirrhosis through early diagnosis. Patients and Methods This study was designed to be case control study; it was conducted on 70 patients selected from Internal Medicine and Hepatology outpatient clinics and inpatient wards at Ain Shams University Hospitals from (Jun/2017 to Jul 9/2018) and 20 healthy subjects as control group. Results NASH patients had more obesity (BMI 30) (83.3%) than both simple steatosis patients (57.5%) and control (55.0%). NASH patients had higher BMI as compared to simple steatosis patients and control (p value =0.01). The present study revealed that there is a statistically significant difference between groups according to IL6 (P > 0.001) as IL6 was positive in 70% of patients with NASH while in patients with simple steatosis and control was positive in 25%, 20% respectively. Conclusion NAFLD is a highly prevalent condition, shares many features of the metabolic syndrome (MetS), a highly atherogenic condition. Recommendations Large scale multi-centre studies are recommended to study the prevalence of NAFLD in Egypt. Further studies on the effect of presence of steatosis and increased risk of hepatocellular carcinoma.
Background: Abdominal trauma in pediatrics is common. Abdomen is the most common site of initially unrecognized fatal injury in traumatized children. Aim of the Work:To analyse the value of conservative treatment versus early operative intervention for solid organs injury in the pediatric age group with blunt abdominal trauma. Patients and Methods:The study was carried out by collecting data from a random group of 140 children whose ages ranged from 6 to 16 years who suffered from abdominal trauma associated with solid organ injury, during the period between January 2017 to December 2020, at Ain Shams University hospital, Ahmed Maher teaching hospital and Nasser Institute. A clinical examination was signed for the patients, vital signs were evaluated, the necessary laboratory investigations were carried out, and FAST was performed on the abdomen in the emergency department. Also CT abdomen and pelvis was done on haemodynamic stable patients or after stabilization. Results:The study showed that periods of hospital stay were significantly higher in the surgical treatment group compared to conservative treatment group. Also blood transfusion, need of ICU hospitalization, need of mechanical ventilation and mortality were significantly higher in the surgical treatment group compared to conservative treatment group. The research showed the success of conservative treatment in the treatment of traumatic abdominal injuries, which resulted in injury to the spleen and liver in children, especially low-grade injuries, and that conservative treatment is safe and less expensive compared to surgical intervention. We also support the expansion of the use of interventional radiology in children, as it greatly reduces the child's exposure to surgical intervention. Conclusion:The present study confirmed the effectiveness of NOM in patients with liver and splenic injuries, suggesting a safe and effective therapeutic approach. According to these findings, the majority of patients can be treated with NOM in a less invasive manner, avoiding unnecessary laparotomies. Hemodynamic stability together with injury grading scale will provide a good plan for management.
Implementing the findings of this molecular analysis could have a major clinical and nationwide economic impact on world health, especially in developing countries.
Background CD155-dependent signals not only influenced net tumor growth but also responsiveness to immune checkpoint therapies. Thus, blocking CD155 could be a rational strategy to improve current immunotherapeutic Aim of the work To assess CD155 in newly diagnosed Low grade B non Hodgkin Lymphomas as prognostic marker for remission Patients and methods CD 155 measured by Ellisa at the time of diagnosis of 50 patients newly diagnosed low grade B non Hodgjen Lymphomas and the remission status followed up prospectively at 3 and 6 months in hematology unit at Ain Shams University Hospital Results there were high statistically significant difference between CD155 level and cytogenetic risk and Eligibility for auto transplantation, there were statistically significant difference between CD155 level and B symptoms, there were high statistically significant difference between CD155 level and Radiology stage, BM infiltation, protocol after 3months, There were high statistically significant difference between CD155 level and Radiology stage, BM infiltration, CBC after 6 months There were high statistically significant difference between CD155 level and non Remission and CD155 had Sensitivity88.46% and Specificity75% as poor predictor of remission Conclusion The CD155 level is prognostic factors for remission in Low grade B non Hodgkin Lymphomas as high CD155 level is poor prognostic factors for response and remission with Sensitivity 88.46%and Specificity75. %
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