Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Exome sequencing is now mainstream in clinical practice. However, identification of pathogenic Mendelian variants remains time-consuming, in part, because the limited accuracy of current computational prediction methods requires manual classification by experts. Here we introduce CAPICE, a new machine-learning-based method for prioritizing pathogenic variants, including SNVs and short InDels. CAPICE outperforms the best general (CADD, GAVIN) and consequence-type-specific (REVEL, ClinPred) computational prediction methods, for both rare and ultra-rare variants. CAPICE is easily added to diagnostic pipelines as pre-computed score file or command-line software, or using online MOLGENIS web service with API. Download CAPICE for free and open-source (LGPLv3) at https://github.com/molgenis/ capice.
Economic growth differences across regions and cities can only be partly explained by standard explanations in economic geography. One reason for this might be the neglect of the psychological make-up of cities and its citizens. To assess the value added of incorporating psychological factors alongside the more standard explanations, this paper tests the relevance of personality traits for economic growth for a sample of UK cities. We argue that Neuroticism and Conscientiousness, and the traits that make up entrepreneurship culture help to explain urban growth differences. The personality scores of 4400,000 UK residents are combined with economic data for 63 UK cities from 1981 to 2011. We find that both Neuroticism and entrepreneurship culture matter for economic growth. Our main contribution is that geographically clustered personality traits help to understand economic growth differences, and add explanatory power over and above standard determinants, also when the recursive relationship between personality traits and economic growth is taken into account.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.