Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results. Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.
Функциональная активность микробиоты кишечника при метаболическом синдроме ГБОУ ВПО "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации, г. Тюмень (ректор -член-корр. РАН И.В. Медведева) Курмангулов А.А.*, Дороднева Е.Ф., Исакова Д.Н.Актуальность. Метаболический синдром (МС) является мультифакторным заболеванием с включением в патогенез многих систем и органов, в том числе и пищеварительной системы. Накопленные данные о существенной роли микроорганизмов во многих метаболических процессах в организме человека позволяют предположить участие микробиоты в развитии пато-логических состояний, в том числе и при МС. Цель исследования. Изучить качественные и количественные характеристики функциональной активности микробиоты ки-шечника у лиц с МС. Материалы и методы. В исследовании принимали участие 85 человек с МС, разделенных на 4 группы в зависимости от зна-чений ИМТ. Определение короткоцепочечных жирных кислот(КЖК) в кале проводилось с помощью газожидкостного хро-матографического исследования. Результаты. Хроматографическое исследование кала позволило выявить изменения как качественных, так и количествен-ных характеристик функциональной активности микробиоты кишечника у людей с МС. Степень выраженности нарушений микробиоты коррелирует с показателем ИМТ. Во всех группах с избытком массы тела отмечено снижение общей метаболи-ческой активности облигатных микроорганизмов. При ожирении 2-й степени повышается активность аэробных популяций микроорганизмов, преимущественно факультативных и остаточных штаммов. МС с ожирением 3-й степени сопровождается наиболее существенными изменениями в копрологическом профиле КЖК с активизацией протеолитических микроорга-низмов. Выводы. Полученные данные позволяют предположить наличие патогенетических детерминант между ожирением при МС и микробиотой кишечника. В связи с этим необходим дальнейший поиск причинно-следственных связей возникновения и прогрессирования метаболических нарушений с участием микробиоты кишечника при МС. Ключевые слова: метаболический синдром, ожирение, микробиота, запор, короткоцепочечные жирные кислоты. Actuality: The metabolic syndrome (MS) is a multifactorial disease involved in the pathogenesis of many systems and organs, including the digestive system. Accumulating evidence signify the role of microorganisms in many metabolic processes and suggest human microbiota involvement in the development of different pathologic conditions, including the MS. The aim: To evaluate the qualitative and quantitative characteristics of the functional activity of intestinal microbiota in individuals with MS. Functional activity of intestinal microbiota with metabolic syndrome Materials and methods:The study involved 85 subjects with MS divided into 4 groups according to BMI. Determination of the short chain fatty acids in the feces was carried out by gas-liquid chromatographic studies. Results: Chromatographic examination of feces revealed changes in both qualitative and quantitative characteristics of the functional activity of the...
Objectives to determine the main types of structuring information of navigation systems in medical organizations of the Russian Federation and evaluate their compliance with the principles of lean production. Material and methods. A structural analysis of the types of information presentation in navigation systems was based on the publications selected from the E-library, Medline, Scopus, PubMed and the Cochrane Library databases. The research process included the use of research methods for law, historical, descriptive-analytical methods, content analysis. Results. The structuring of navigation information can be done according to numerological, architectural, routing, alphabetical, structural, functional and combined principles. The optimal choice of the principle of organizing information should depend on how detailed the navigation system is, on the analysis of the architectural solutions used for a medical organization and on the calculation of navigation objects. It is possible to increase the efficiency of structuring navigational information using an appropriate color scheme, infographic and compositional solutions. When improving the navigation systems of medical institutions as a part of lean hospital management, it is necessary to audit all available navigation elements to determine the principle of structuring the information. Conclusion. The effective visualization of a medical institution is the provision of clear and understandable navigational information. One of the most effective methods to systematize the navigation information is its structuring.
Aim. To study the association between depression and metabolic cardiovascular risk factors, hypertension (HTN) and its control in a random sample of Tyumen Oblast population of men and women aged 25-64 years.Material and methods. The study object was a random sample of the population of the Tyumen and the Tyumen Oblast aged 25-64 years, examined as part of the ESSE-RF epidemiological study. The study included 1658 participants. Among them, 30,3% (n=503) were men, while 69,7% (n=1155) — women. Mean age was 48,9±11,4 years. The prevalence of metabolic risk factors (hyperlipidemia, carbohydrate metabolism disorder, obesity), hypertension and the likelihood of its control in men and women with different levels of depressive disorders diagnosed using the HADS scale were assessed.Results. Compared with participants without depression, persons with psychological disorders were significantly more likely to have HTN (55,5% vs 47,6%, p<0,01), elevated levels of total cholesterol (TC) (63,9% vs 54,0%, p<0,01) and low-density lipoproteins (LDL) (66,7% vs 60,3%, p<0,05), carbohydrate metabolism disorders (8,3% vs 5,2% p<0,05), obesity (49,2% vs 37,7%, p<0,01). Significantly more often hypertensive subjects without depression took antihypertensive drugs effectively (odds ratio (OR) — 1,747, 95% confidence interval (CI), 1,001-3,053) and controlled blood pressure (OR — 1,533, 95% CI, 1,05-2,36). There was no association between the use of antihypertensives and the level of depressive disorders. Among women with depression (HADS>7), dyslipidemia (65,5% vs 57,4% for TC, p<0,05; 71,0% vs 62,9% for LDL, p<0,05), carbohydrate metabolism disorders (10,1% vs 5,2%, p<0,01), obesity (53,3% vs 43,2%, p<0,01), HTN (60,6% vs 45,6%, p<0,01) were more common. Men with clinical depression were more likely to have HTN (69,0% vs 47,7%, p<0,05), with a high level of depression — hyperlipidemia (58,9% vs 46,7% for TC, p<0,05; 67,1% vs 53,9% for LDL, p<0,05). Women with elevated depression levels were less likely to take antihypertensive drugs (30% vs 49,4%, p<0,01) and control hypertension (13,8% vs 21,2%, p<0,05).Conclusion. The data obtained confirm the association of depressive disorders with metabolic risk factors and the likelihood of HTN control, which is especially significant among women.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.